It is not natural to take vitamin E in high amounts in a pill form. You should take vitamin E in small amounts from food. Best sources are nuts, olive oil sunflower oil and sesame oil. In food supplements vitamin E is synthetic and in high doses, and the consumption of synthetic vitamin E increases the incidence of cancer. Vitamin E does not prevent heart disease. Even natural vitamin E supplements are useless and dangerous, because they are in high amounts. You should not consume more than the RDA of vitamin E. 400IU is a huge and dangerous dosage.
Vitamin E supplements may harm patients with head and neck cancer
Editor's Note: This unexpected adverse result really cautions us from taking supplements to prevent or treat cancer. We all know the benefits of eating antioxidant-rich fruits and vegetables in promoting good health. On the contrary, high-dose supplements may not produce the same health-promoting effects we wish for.
Vitamin E is a type of antioxidant present in our foods which can prevent or slow the oxidative damage to our body so do not avoid Vitamin E-rich foods based on the result of this study. Vitamin E is not present in foods in mega dose. It can be found in nuts & seeds, whole grains, green leafy vegetables, vegetable oil and liver oil.
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Vitamin E linked to 9,000/million User Deaths
British Study
Finds Vitamin Supplements May Increase Cancer Risk
From Consumer Affairs.com Oct 01 '04
Not only do
vitamin supplements not protect against gastro-intestinal cancer, they may slightly
increase the risk of cancer, according to a systematic review and
meta-analysis of previously published randomised trials in this week’s issue
of THE LANCET, a leading British medical journal.
If the findings are
correct, 9,000 in
every million users of such vitamin supplements will die prematurely as a
result of taking something they think is good for them. Miller said his team
pulled together results from 19 studies representing almost 136,000 people
and found that those taking high doses of vitamin E (400 international units
or greater) had a 5 percent greater risk of dying over four years than those
who were taking either less than 150 IU or a placebo.
"The prospect that vitamin pills may not only do no good but also
kill their consumers is a scary speculation given the vast quantities that
are used in certain communities,” David Forman of the University of Leeds and
Douglas Altman, Cancer Research UK, said in an accompanying commentary.
The researchers cautioned that the findings are preliminary and
"(do) not offer convincing proof of hazard," pending further
studies.
The mortality analysis in Bjelakovic and colleagues’ review is work in
progress, and does not offer convincing proof of hazard. In the event that a
hazard is established from a complete review, these researchers will need to
identify which specific interventions are associated with any risk. It is
unlikely that all supplements will exert a similar effect and it will be
vital to establish the safety profile for those with demonstrated benefits.”
"The human diet is a complex mix of oxidants and antioxidants.
Excess oxidants can cause cancer by inducing gene mutations," said Goran
Bjelakovic, a professor at several European university, the study's lead investigator.
The investigators identified 14 randomised trials totalling over
170,000 participants. Overall, the results did not show any protective effect
of supplementation with beta-carotene, vitamins A, C, E, and selenium (alone
or in combination) compared with placebo on oesophageal, gastric, colorectal,
pancreatic, and liver cancer incidences.
In half the trials, there was a small but statistically significant
increase in mortality among people taking antioxidants compared with
placebos. The results also showed that two combinations of supplements were
associated with increased mortality risk: beta-carotene and vitamin A, and
the combination of beta-carotene and vitamin E.
Four of the trials suggested that selenium was associated with a
reduction in gastro-intestinal cancer risk.
“We could not find evidence that antioxidant supplements can prevent
gastrointestinal cancers; on the contrary, they seem to increase overall
mortality. The potential preventive effect of selenium should be studied in
adequate randomised trials," Dr. Bjelakovic said.
Previous studies have failed to demonstrate that antioxidant vitamin
supplements reduced the risk of heart disease among people at high risk of
vascular disease.
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Another risk that of
heart attacks
Another
bit of the naturalistic, good for the body, claims bites the dust—at least
for people who demand evidence. One claim
is that Vitamin E is healing, and thus promotes recover from heart
attacks. Thirty-five years ago I heard
on the radio a medical doctor--who was into the naturalistic lore—that his
patients were having exceptionally rapid recoveries from heart attacks
because of vitamin E. Sounded
convincing, except for its source and that if this was the case, the medical
establishment would have within a few years been giving vitamin E to
accelerate recovery from heart attacks.
A second claim was that vitamin E reduces the risk of cancer. Now a study shows. Recently published large population studies
show that it has a slight effect to the contrary, raises the risk. --jk
Health Day, March 05
Vitamin E Ups Heart Failure Risk
Vitamin E doesn't help prevent cancer or
cardiovascular disease and can, in fact, increase the risk of heart
failure. That's the conclusion of an
extended trial of thousands of older people with a history of cardiovascular
disease or diabetes who were randomly assigned to take either 400 I.U. of
vitamin E or a placebo.Study also finds supplement doesn't prevent cancer or heart disease by Serena Gordon, HealthDay Reporter | Mar 15 '05 The results, published in the March 16 issue of the Journal of the American Medical Association, found there was up to a 19 percent increase in the risk of heart failure in the study volunteers who took vitamin E compared to those on the placebo. "I don't think people have to panic" if they've been taking vitamin E, said study author Dr. Eva Lonn, a professor of medicine at the Population Health Research Institute at McMaster University in Hamilton, Ontario, Canada. She noted that the incidence of heart failure was lower in study participants than the incidence of either heart attack or stroke. And it's also possible the findings were simply due to chance, because so far other studies haven't shown this side effect, Lonn said. Still, she added, most other studies haven't looked specifically for heart failure, either. In younger, healthier people, Lonn said, vitamin E is probably safe, "but I think it would be a waste of time." She said numerous studies, including hers, have found no protective effect from vitamin E against heart disease or cancer. At least one expert from the dietary supplement industry disagrees with Lonn, however. "This study is not the final word," said Annette Dickinson, president of the Council for Responsible Nutrition, a trade association representing the dietary supplement industry. "This was a study done on older people with serious preexisting disease, taking a number of medications, and their findings have not been confirmed in other studies." "I think that healthy people can still be confident in vitamin E," Dickinson added. "A number of studies have shown benefits in some types of cancers, eye diseases, and neurological conditions, such as Alzheimer's." The new study is a continuation of the Heart Outcomes Prevention Evaluation (HOPE) trial, which included data on 9,541 people who were over 55 and either had a history of heart disease or diabetes. The original study was conducted from December 1993 through April 1999. Results of that study were published in the New England Journal of Medicine in 2000. Study volunteers were randomly chosen to receive either 400 I.U. daily of vitamin E or a placebo. Lonn said many researchers felt the original trial was conducted for too short a period of time. It was suggested that if vitamin E were going to show a benefit, it would likely come from long-term use. The Ongoing Outcomes (HOPE-TOO). Almost 4,000 people from the original study consented to continuing in the extended study. The researchers were also able to obtain follow-up information through medical records for many people who didn't stay in the study. HOPE-TOO found no evidence that vitamin E protects against cancer or cardiovascular disease. In fact, the researchers found that the rate of heart failure increased in people taking vitamin E. Lonn said the overall increase in heart failure risk was 13 percent. For heart failure requiring hospitalization, the risk was increased by 19 percent in the vitamin E group, she said. While Lonn said the mechanism that might cause vitamin E to increase the risk of heart failure isn't clear, it may be that in the presence of oxidative stress, vitamin E may act as a pro-oxidant, rather than an antioxidant. But, again, Lonn said she doesn't think anyone who's been taking vitamin E needs to worry. Her biggest concern, she said, is that many people who take vitamins and other dietary supplements may think they don't need to take other steps to prevent cancer and heart disease, such as getting enough exercise and eating right. Dickinson said, "There needs to be more evaluation of these findings. I agree that it's a good idea to examine those results, but I think it's not likely to show it's a chance finding." More information To learn more about vitamin E, visit the National Institutes of Health's Office of Dietary Supplements.
Wipe the other cheek
From Health Day Jan 05
The conference followed the release of a John Hopkins study
in November that found elderly, ill patients who took vitamin E daily at
doses of 400 International Units (IUs) or more suffered a 6 percent increase
in mortality compared to those who took placebos.
MORE
CONFIRMATION OF VITIMAN E RISK
People Not Heeding Vitamin E Warnings
Many taking high daily doses despite evidence it may be harmful
by
Alan Mozes, HealthDay Reporter | Jul 19 '05
Many
Americans still take high daily doses of vitamin E despite mounting evidence
that the vitamin offers no health benefit and could be dangerous, a new study
finds. The researchers found that just
over 11 percent of American adults routinely consume at least 400 IUs of
vitamin E on a daily basis. Another 26 percent of American adults take
supplements that include lower amounts of the vitamin. Reporting in the July 19 issue of Annals of Internal Medicine, the authors
referred to a range of recent studies that suggested vitamin E
supplementation in doses at or exceeding 400 IUs may increase the risk for
premature death from chronic illness such as heart disease and cancer. "Basically, what we're trying to do is
let folks know that many Americans are still consuming too much vitamin E,
and that too much is really not that good," said study co-author Ali H.
Mokdad, of the Chronic Disease Center at the Centers for Disease Control and
Prevention in Atlanta.
Vitamin
E supplements in the 400 IU range far exceed the current federally
recommended dietary allowance (RDA) guideline set to reflect the daily
nutritional needs of most healthy men, women and children. The RDA for vitamin E
--according to the National Institutes of Health (NIH)-- is 22.5 IUs for
adults. The NIH
points out that vitamin E deficiency is rare, noting that the nutrient is
found naturally in many food sources such as plant oils (including vegetable
oil and margarine), leafy green vegetables, whole grain cereals, liver, egg
yolks, milk, nuts, seeds and butter.
Mokdad and his colleagues analyzed vitamin E supplementation data
among more than 4,600 white, black and Mexican-American adult men and women
who had been included in the 1999-2000 National Health and Nutrition
Examination Survey.
All
the participants had completed interviews and questionnaires on their daily
dietary intake, and all underwent blood tests and neurological, fitness and
oral health evaluations. White adults
were also generally more likely to take vitamin E supplements, as were those
patients with a history of heart disease, stroke or diabetes. Those who regularly took vitamin E supplements
were also more likely to ingest supplements that included vitamin C and
beta-carotene. The researchers suggested that this combination of supplements
further added to the potential harmful effects related to the ingesting of
high doses of vitamin E. The authors
concluded that high-dosage vitamin E supplementation is common, and that
concerns about the practice should be raised by health-care professionals who
could advise their patients of potential health risks.
complicating efforts to promote accurate public
health information about vitamin E.Both Mokdad and his colleague, Dr. Umed A. Ajani, said that the exact mechanism by which high-dose vitamin E supplementation poses health risks is not yet fully understood. However, they emphasized, the danger is real. "We know there is an increased risk, and at this point this affects a sizeable proportion of the U.S. population," Ajani said. "There was this theory that antioxidants such as vitamin E will lead to less blockage in the arteries," said Mokdad. "But there have been several clinical trials since that show that, in reality, this is not true. Unfortunately there was a lot of media attention given to the antioxidant theory, and it seems people haven't kept up with the most recent data that showed, in fact, that it may harm you a little bit."
Both
Mokdad and Ajani agreed that vitamin supplementation overall is ripe for
abuse and poorly understood.
"There may be some supplements out there that are good for people
to take now and then," Ajani added. "But in the case of vitamin E,
the research does not support any benefit, and in fact it may harm you."
Dr.
Jay Brooks, chief of hematology/oncology at the Ochsner Clinic Foundation in
New Orleans, concurred. "Everyone thinks that
taking vitamins and supplements is perfectly OK to do," Brooks said.
"But these are active drugs, and we don't understand completely what
they do. So, I do not recommend to any of my patients to be taking extra
dosage of vitamins, unless they're involved in a research study." "I know of no
disease . . . that can be prevented or treated by taking vitamin E,"
Brooks added. "So, I don't take it personally to prevent prostate cancer
or other diseases. We just don't know if it works, and it may actually be
detrimental."
More informationFor more on vitamin E, check out the National Institutes of Health's Office of Dietary Supplements. SOURCES: Ali H. Mokdad, Ph.D., and Umed A. Ajani, M.D., Chronic Disease Center, CDC, Atlanta; Jay Brooks, M.D., chief, hemotology/oncology, Ochsner Clinic Foundation, New Orleans; July 19, 2005, Annals of Internal Medicine |
New study reveals vitamin E dangers: Don't buy a word of it!
By Jenny Thompson on 11/27/2010
Sometimes
the mainstream media acts like a hulking, simple-minded, Frankenstein. Here's the latest from "Frank" on vitamin E: "Vitamin E cause stroke. Me no like stroke. Me no like vitamin E! Argh!"
Thanks, big guy. That's really...not helpful at all.
It's alive!
With headlines such as, "Vitamin E increases risk of internal bleeding stroke," and "Vitamin E could trigger a stroke," the mainstream media has, once again, completely botched the reporting.
For instance, here's a Washington Post blog article: "It turns out that taking Vitamin E, while reducing risk of ischemic stroke by about 10 percent, actually increases risk of the more-dangerous hemorrhagic stroke by 22 percent."
Well, no, it doesn't "turn out"--as if, finally, this is the end of the story. And there's zero evidence that a quality vitamin E supplement would "actually increase risk" of hemorrhagic stroke.
This vitamin E news isn't based on a clinical trial. It was a meta-analysis of several clinical trials, so it's open to all kinds of interpretation.
Pitchforks and torches
And you know who saw right through all that? Washington Post readers. It was like they became a mob of angry villagers, grabbing torches and pitchforks to go after the mainstream Frankenstein.
In the comment section included with the blog article, several readers asked about the forms of vitamin E used and the dosages. In comment after comment there are intelligent questions that SHOULD have been raised by the blogger, who instead just parroted the conclusion of the study.
So what's the real deal with the meta-analysis? Well, it's a mess. As usual!
First of all, many of the subjects in these studies weren't at all healthy to begin with.
One study enrolled only smokers--more than 28,000! That's a HUGE cohort already at risk of stroke. Another study recruited only subjects who had experienced cardiovascular disease events. And in two studies, a combined total of more than 17,500 subjects were at high risk of cardiovascular disease.
And vitamin E played a role in their strokes? Riiiight.
But wait. It goes from very bad to much worse...
Of the nine studies included in the analysis, four of them used a synthetic form of E known as dl-alpha. Which is simply junk. In fact, Dr. Spreen recommends that dl-alpha only be used topically because, over time, it may actually do harm when taken internally.
The subjects in those four "synthetic" studies accounted for about half of all the subjects in the combined studies. Which means that half of this meta-analysis is based on junk.
So here's the ACCURATE headline for any media report on this study: "Junk form of vitamin E may slightly increase stroke risk among unhealthy patients."
Honestly, I don't have all the numbers, so my made-up headline is possibly misleading. But I'll bet it's more accurate than the blatantly absurd headlines suggesting that any vitamin E supplement increases hemorrhagic stroke risk.
You can put a torch to that one and stick a pitchfork in it.
Vitamin E increases all-cause mortality
Nov 10, 2004
New Orleans, LA -
Driving a final nail in the coffin for vitamin E, a meta-analysis of the
popular supplement indicates that doses >400 IU/day can increase the risk of
death from any cause. Vitamin-E capsules typically contain 400 to 800 IU.
"Our study results do not support the use of
high-dose vitamin-E supplements," lead author on the study, Dr Edgar Miller III (Johns Hopkins
University, Baltimore, MD), commented. "If people are taking a multivitamin,
they should make sure it contains no more than a low dose of vitamin E."
Miller presented the results from his study here in a
poster at the American Heart Association (AHA)
Scientific Sessions 2004; the
study also appeared simultaneously online in the Annals of Internal Medicine.[1] In an interview with heartwire,
Miller pointed out that the medical community has known for some time that
vitamin E has at best a null effect, but that patient numbers from individual
studies showed no more than a slight trend toward increased mortality. In the
meantime, the general public has remained largely enamored of vitamin E,
believing it to have benefits ranging from antiaging to anticancer properties.
"As a doctor, you fight your battles, and in the
past, if patients came in saying they were taking vitamin E, that wasn't a
battle worth fighting. You fight for ACE inhibitors and beta blockers,"
Miller explains. "This new study now gives physicians some firm evidence
to use in counseling their patients. If your patients are trying to make a
choice about whether or not to take vitamin E, this shows that they are not
going to live longer, which is often one reason why they want to take it, and
in fact they may be more likely to die."
Fighting the right battles
Miller et al's study combined data from 135 967
participants in 19 clinical trials of vitamin E, taking doses ranging from 16.5
IU/day to 2000 IU/day (median 400 IU/day). Trial participants ranged in age
from 47 to 84 years of age, and most of the populations studied were at high
risk for chronic diseases in general and coronary heart disease in particular.
Nine of the trials looked at vitamin E alone, and 10 looked at vitamin E in
combination with other vitamins and minerals.
The investigators report that
nine of 11 trials testing vitamin E doses >400 IU/day showed increased risk
of all-cause mortality, whereas vitamin E doses lower than 400 IU/day showed no
increased mortality. In a dose-response analysis, the authors found progressive
increases in mortality for successively larger doses of vitamin E, starting at
doses higher than 150 IU/day. "The increase in all-cause mortality has
obvious public-health importance and represents a qualitative departure from
previous findings," Miller et al write in their paper.
Mortality risk by vitamin E dose
|
Vitamin E
dose (IU/day)
|
Risk ratio*
|
95% CI
|
|
50
|
0.99
|
0.96-1.03
|
|
100
|
1.00
|
0.97-1.04
|
|
200
|
1.01
|
0.98-1.05
|
|
500
|
1.04
|
0.99-1.08
|
|
1000
|
1.06
|
1.00-1.11
|
|
2000
|
1.08
|
1.01-1.14
|
*Adjusted for other vitamins and minerals
To download table as a slide, click on slide logo below
To heartwire, Miller acknowledged that
"there are going to be arguments about this paper"; indeed, Miller
had already received a flurry of emails from patients and nutraceutical
companies before noon on the day that his paper and poster were published. But
other experts attending the AHA sessions welcomed the new data. Dr Raymond Gibbons (Mayo Clinic, Rochester,
MN) alerted members of the media to Miller et al's poster, calling it
"important" news that was not filtering out to the wider public.
Likewise, AHA president Dr Alice Jacobs (University Medical Center, Boston, MA) said
the paper will help physicians provide better care. "Our concern has been
that patients who are taking multiple medications might be taking vitamin E,
and not something that is evidence-based, of proven benefit," she told heartwire.
"We finally have some data that we can use in discussions with our
patients."
BREAKING: Cancer-Preventing Pills Backfire
This bitter pill may contribute to cancer—not prevent
it.
Two of
the most promising supplements for preventing prostate cancer—vitamin E and
selenium—don’t hold up to their hype. In fact, a new study published in this
week’s JAMA suggests that
vitamin E may actually encourage prostate cancer to develop.The supplements piqued researchers’ interest when previous studies that the pills primarily for other health conditions seemed to show a reduction in prostate cancer as a side effect. So Eric Klein, M.D., of the Cleveland Clinic and his colleagues launched a study in 2001 to test their effects directly to prevent prostate cancer in more than 35,000 men.
These volunteers were broken down into four groups: one took just 200 mg selenium daily, another took 400 IU vitamin E, one took both supplements, and one took placebos. In 2008, the researchers stopped having the volunteers take supplements since they didn’t seem to make any difference in prostate cancer rates. But the scientists continued keeping tabs on the volunteers.
Earlier this year, they tallied up the latest findings. Results showed that the men taking just vitamin E had a 17 percent higher risk of getting prostate cancer than those in the other groups. For every 1,000 men in the study, 65 in the placebo group developed prostate cancer vs. 68 in the vitamin E group.
More from MensHealth.com: Are You at Risk for Prostate Cancer?
Klein says that he and his fellow researchers don’t yet know how vitamin E might bring on prostate cancer. However, he had the same message as other recent disappointing vitamin trials: “My general advice about nutritional supplements is don’t expect they’ll be beneficial unless there’s a well-done scientific trial that shows they’re beneficial. People should not think of vitamins as innocuous substances.”
As for real ways to prevent prostate cancer? “Diet and exerise,” Klein advises. “It’s just what people don’t want to hear, but it’s exactly what they need.” In a 2011 study, men with a history of inactivity were three times more likely than their active counterparts to develop prostate cancer.
